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Advances in treatment of human trypanosomiasis
Novotná, Kristýna Klára ; Mach, Jan (advisor) ; Grekov, Igor (referee)
Sleeping sickness is a human disease found in sub-saharan Africa, and is caused by a parasitic protozoan Trypanosoma brucei. Trypanosoma brucei species infects various mammals, however, only Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense subspecies are resistant to trypanolytic factors found in human blood serum. This work briefly summarizes known operating mechanisms of trypanolytic factors and resistance mechanisms of trypanosomes to these factors. The work covers mainly description and summarization of current diagnostic methods of sleeping sickness and used trypanocidal drugs. Majority of introduced methods shows high levels of sensitivity and specificity, however, for poor, disease affected areas they are often way too expensive. Prescribed drugs are expensive as well, and what's more, they are often ineffective against both subspecies and have severe side effects. Last part of the work is dedicated to potential development of new medicaments.
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Analysis of Mitochondrial Bioenergetics of Bloodstream Form of Trypanosoma Brucei
IELANSKYI, Mykyta
Trypanosoma brucei is a pleomorphic extracellular parasite that represents significant scientific interest due to its early divergence from the eukaryotic lineage and its range of unique adaptations. Among these adaptions are some metabolic pathways that are unconventional and are not fully understood. Among such pathways are the catabolic pathways of the parasite's bloodstream form, in particular those responsible for ATP supply to the parasites' reduced mitochondrion. This thesis investigates the nature of these pathways as well as interactions between them.
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Advances in treatment of human trypanosomiasis
Novotná, Kristýna Klára ; Mach, Jan (advisor) ; Grekov, Igor (referee)
Sleeping sickness is a human disease found in sub-saharan Africa, and is caused by a parasitic protozoan Trypanosoma brucei. Trypanosoma brucei species infects various mammals, however, only Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense subspecies are resistant to trypanolytic factors found in human blood serum. This work briefly summarizes known operating mechanisms of trypanolytic factors and resistance mechanisms of trypanosomes to these factors. The work covers mainly description and summarization of current diagnostic methods of sleeping sickness and used trypanocidal drugs. Majority of introduced methods shows high levels of sensitivity and specificity, however, for poor, disease affected areas they are often way too expensive. Prescribed drugs are expensive as well, and what's more, they are often ineffective against both subspecies and have severe side effects. Last part of the work is dedicated to potential development of new medicaments.
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